| 发明名称 |
TUMOR SUPPRESSOR WAF1 |
| 摘要 |
A human gene, WAF1, has been identified which is induced by wild-type but not mutant p53 in human brain tumor cells. The gene is located on chromosome 6p21.2 and directs the synthesis of an 18.1 kd protein. Introduction of WAF1 cDNA suppresses growth of human brain and colon tumor cells. The WAF1 gene and protein are useful inter alia for diagnosis and treatment of human tumors.
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| 申请公布号 |
WO9513375(A1) |
申请公布日期 |
1995.05.18 |
| 申请号 |
WO1994US12936 |
申请日期 |
1994.11.10 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
VOGELSTEIN, BERT;KINZLER, KENNETH, W. |
| 分类号 |
A61K38/00;A61P35/00;C07K14/47;C12N15/113;C12N15/12;(IPC1-7):C12N15/12;C12N15/11;C12N15/62;C07K16/18;A61K38/18;A61K48/00;C12Q1/68;G01N33/574 |
主分类号 |
A61K38/00 |
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