发明名称 |
Pharmaceutical preparation for percutaneous absorption |
摘要 |
The present invention provides a pharmaceutical preparation for percutaneous absorption comprising a drug-impermeable substrate having provided thereon an adhesive layer comprising a drug and a drug dissolution aid, characterized in that said adhesive is composed of a copolymer essentially consisting of 5 to 35 wt % of N-vinyl-2-pyrrolidone and 65 to 95 wt % of an acrylic acid ester, 3 to 30 wt % of a homopolymer of N-vinyl-2-pyrrolidone is contained in said adhesive layer as the drug dissolution aid, and said drug is a hydrophilic drug having a saturation solubility of 6 to 50 wt % to N-vinyl-2-pyrrolidone. Where the hydrophilic drug is Piroxicam, it is preferred to use a polyoxyethylene alkyl ether and/or a fatty acid alkylolamide as an absorption enhancer in combination.
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申请公布号 |
US5413776(A) |
申请公布日期 |
1995.05.09 |
申请号 |
US19920064361 |
申请日期 |
1992.12.22 |
申请人 |
SEKISUI CHEMICAL CO., LTD. |
发明人 |
SUZUKI, TARO;FUKUDA, MUTSUMI;YONETO, KUNIO |
分类号 |
A61K9/70;A61K31/54;A61K47/18;A61K47/32;A61L15/58;A61P29/00;(IPC1-7):A61F13/02 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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