| 摘要 |
An indole derivative represented by general formula (I), each isomer thereof or a mixture of the isomers, a physiologically acceptable salt thereof, and a solvate thereof, wherein R1 represents (a) or (b); R2 represents optionally substituted phenyl; and R3 represents hydrogen, methyl or ethyl. This derivative has a potent and selective antagonism against intestinal 5-HT3 receptors when compared with known 5-HT3 antagonists and can well retain the effect for long, so that it is particularly useful for preventing or treating digestive tract disorders such as irritable bowel syndrome and diarrhea.
|
