发明名称 |
Benzyo-fused thiazolidinyl terminated alkylamino ethylnyl alanine amino diol compounds for treatment of hypertension |
摘要 |
Compounds characterized generally as benzo-fused thiazolidinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I <IMAGE> (I) wherein A is selected from CO and SO2; wherein X is selected from oxygen atom and methylene; wherein B is a benzo-fused thiazolidinyl group; wherein R1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; wherein R2 is phenylmethyl; wherein each of R3 and R5 is hydrido; wherein R4 is selected from -(CH2)q-C 3BOND C-V wherein V is selected from hydrido and methyl; wherein R6 is cyclohexylmethyl; wherein R7 is selected from isobutyl, cyclopropyl and cyclopropylmethyl; wherein q is a number selected from zero through three, inclusive; and wherein n is a number selected from zero through three, inclusive; or a pharmaceutically-acceptable salt thereof.
|
申请公布号 |
US5409945(A) |
申请公布日期 |
1995.04.25 |
申请号 |
US19940198425 |
申请日期 |
1994.02.22 |
申请人 |
G. D. SEARLE & CO. |
发明人 |
HANSON, GUNNAR J.;MANNING, ROBERT E. |
分类号 |
C07D295/12;A61K31/395;A61K31/425;A61K31/535;A61K31/5375;A61K31/54;A61K31/55;A61P9/00;A61P9/12;A61P13/02;A61P15/00;A61P27/02;A61P27/06;A61P43/00;C07D265/06;C07D265/30;C07D265/32;C07D267/10;C07D277/04;C07D285/00;C07D295/13;C07D498/08;(IPC1-7):A61K31/425;C07D277/62;C07D277/64 |
主分类号 |
C07D295/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|