| 摘要 |
The invention relates to a process for obtaining an epiderm equivalent cultivated in a defined medium, the corresponding epiderm equivalent, and its utilization for pharmaceutical and/or cosmetic sun-tanning tests. The disclosed produced epiderms are capable of sun-tanning, under ultraviolet rays, or in the presence of psoralenes, for example. The melanocytes present in said epiderm equvalents produce melanine grains which are transferred, as in vivo, into the environning keratinocytes as a function of the stimulation intensity. After application to the reproduced epiderms (and/or in the culture medium) a product to be tested, it is possible to measure its effect for retarding, inhibiting or stimulating said sun-tanning reaction, through various technics.
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