发明名称 |
COMPOUNDS MODIFYING SEROTONINERGIC TRANSMISSION, DIAGNOSTIC AND THERAPEUTIC APPLICATIONS |
摘要 |
Compounds having the following peptide sequence: X Leu Y, wherein X is H or Ala or Leu-Ser-Ala, Y is OH or peptide sequence having from 1 to 10 amino acids, with the terminal carboxy end being amidified by a NH2 group, or esterified by a substituted or non-substituted hydrocarbyloxy, with the proviso that X and Y are not simultaneously H and OH, respectively, The invention also concerns the corresponding compounds wherein the peptide binding group -CO-NH- is replaced by a binding group resisting protease enzymatic degradation, or wherein the peptide backbone comprises one or more intercalated groups making the peptide binding resistant to enzymatic degradation. Also described are compounds comprising a grouping whose spatial structure is substantially identical to that of a peptide of the sequence X-Leu-Y wherein X and Y have the above-mentioned definition.
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申请公布号 |
WO9509868(A1) |
申请公布日期 |
1995.04.13 |
申请号 |
WO1994FR01158 |
申请日期 |
1994.10.04 |
申请人 |
INSTITUT PASTEUR;FILLION, GILLES;ROUSSELLE, JEAN-CLAUDE;MASSOT, OLIVIER |
发明人 |
FILLION, GILLES;ROUSSELLE, JEAN-CLAUDE;MASSOT, OLIVIER |
分类号 |
G01N33/53;A61K38/00;A61K51/00;A61P25/04;A61P25/24;A61P25/26;A61P37/00;C07C229/08;C07C229/22;C07K1/04;C07K1/14;C07K5/06;C07K5/062;C07K5/083;C07K5/103;C07K7/06;G01N33/566;G01N33/577;(IPC1-7):C07K5/062;C07K16/18;A61K38/05;A61K38/06;A61K38/07;A61K38/08;G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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