| 发明名称 |
PHENOLISCHE THIOETHERAMIDE ALS 5-LIPOXYGENASE-INHIBITOREN. |
| 摘要 |
The present invention relates to phenolic thioetheramides of the formula <IMAGE> wherein R1 and R2 are tert-alkyl or phenyl, Alk1 and Alk2 are alkylene; X is sulfur or oxygen, m is 0, 1, or 2; and R is <IMAGE> a) wherein R3 and R4 are hydrogen or alkyl and Alk3 is alkylene; or <IMAGE> b) wherein Y is CH, N, O, or S; R6 is hydrogen, alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl or a heterocyclic amine; and R7 is hydrogen or alkyl. The compounds inhibit 5-lipoxygenase and are useful in the treatment of inflammation and allergic conditions. |
| 申请公布号 |
DE69107851(D1) |
申请公布日期 |
1995.04.06 |
| 申请号 |
DE1991607851 |
申请日期 |
1991.09.05 |
| 申请人 |
G.D. SEARLE & CO., CHICAGO, ILL., US |
发明人 |
MUELLER, RICHARD, AUGUST, GLENCOE, IL 60022, US;PARTIS, RICHARD, ALLEN, EVANSTON, IL 60201, US |
| 分类号 |
A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/445;A61K31/4468;A61K31/495;A61K31/50;A61P29/00;A61P37/08;C07D;C07D211/16;C07D211/58;C07D213/40;C07D279/12;C07D295/18;C07D295/185;(IPC1-7):C07D213/40 |
主分类号 |
A61K31/44 |
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