发明名称 |
23-Oxo(keto) und 23-Imino-Derivate von LL-F28249-Verbindungen. |
摘要 |
The present invention relates to novel 23-oxo (keto) and 23-imino derivatives of LL-F28249 alpha , beta , gamma , delta , epsilon , zeta , theta , i and lambda compounds. These LL-F28249 compounds (collectively) are isolates from the fermentation broth of Streptomyces cyaneogriseus subspecies noncyanogenus having deposit accession number NRRL 15773. The present 23-oxo compounds are prepared by selectively oxidizing suitably protected 23-hydroxy compounds of LL-F28249 components using oxidizing agents. Subsequently, the 23-oxo compounds are converted to the 23-imino compounds. These novel compounds have potent anthelmintic, insecticidal, ectoparasiticidal, nematicidal and acaricidal activity. Compositions containing these 23-oxo and 23-imino derivatives of LL-F28249 also are described herein. |
申请公布号 |
DE3750355(T2) |
申请公布日期 |
1995.04.06 |
申请号 |
DE19873750355T |
申请日期 |
1987.09.03 |
申请人 |
AMERICAN CYANAMID CO., WAYNE, N.J., US |
发明人 |
ASATO, GORO, TITUSVILLE NEW JERSEY 08560, US;FRANCE, DONALD JOHN, PENNINGTON NEW JERSEY 08534, US |
分类号 |
A61K31/365;A01N43/90;A01N49/00;A23K20/195;A61P33/00;C07D493/22;C07H19/01 |
主分类号 |
A61K31/365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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