发明名称 |
Benzoxazepine derivatives useful as squalene synthetase inhibitors. |
摘要 |
Disclosed is a squalene synthetase inhibitor which comprises the compound represented by the formula (I) <CHEM> wherein R1 stands for H or an optionally substituted hydrocarbon group; R2 and R3 independently stand for H, an optionally substituted alkyl group, an optionally substituted phenyl group or an optionally substituted aromatic heterocyclic group; Z stands for a carbon chain containing a double bond or -Z'-C(OH)- (Z' stands for a bond or a straight-chain or branched alkylene chain); the symbol @ stands for a double bond or a single bond; Y stands for an optionally esterified carboxyl group, an optionally substituted carbamoyl group, an optionally substituted hydroxyl group, an optionally substituted amino group or an optionally substituted heterocyclic radical having a protonizable hydrogen; and the ring A is optionally substituted, or a pharmaceutically acceptable salt thereof, and which is useful for the prophylaxis or therapy of hypercholesteremia or coronary sclerosis of mammals. |
申请公布号 |
EP0645377(A1) |
申请公布日期 |
1995.03.29 |
申请号 |
EP19940114939 |
申请日期 |
1994.09.22 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
YUKIMASA, HIDEFUMI;KORI, MASAKUNI;TOZAWA, RYUICHI;SUGIYAMA, YASUO |
分类号 |
C12N9/99;A61K31/55;A61K31/551;A61K31/553;A61K31/554;A61P3/06;A61P43/00;C07D223/16;C07D243/04;C07D243/10;C07D243/12;C07D243/14;C07D243/16;C07D243/24;C07D245/06;C07D255/04;C07D257/04;C07D267/14;C07D267/22;C07D281/10;C07D285/00;C07D417/06;C07D417/12;C07D498/04 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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