| 摘要 |
The present invention relates to penem derivatives, especially to 3 beta -alkenyl-penem derivatives of the general formula <IMAGE> wherein one of R<1> and R<2> is -COR<4>, -CN, -CH2R<5>, halogen, -CH=CHR<6> or Q and the other is hydrogen or lower alkyl or both together are a gamma -lactam ring, R<3> is hydrogen, lower alkyl, arylalkyl, allyl or a radical which can be removed in vivo, R<4> is hydrogen, lower alkyl, lower alkoxy, benzyloxy, amino, lower alkylamino or lower alkyl-lower alkoxyamino, R<5> is hydroxyl, -OCONHR<7>, -OCONH2 or a five- or six-membered heteroaromatic ring containing N, S and/or O and linked via a nitrogen atom, R<6> is -CN or -CHO, R<7> is COCH2Cl, Q is a five- or six-membered heteroaromatic ring containing N, S and/or O and n is 0, 1 or 2, and the pharmaceutically tolerable salts of these compounds. These compounds are good beta -lactamase inhibitors. They can be used, if appropriate mixed with a beta -lactam antibiotic, for the prevention or for the treatment of bacterial infections. |
