NOVEL PROTEINS ISOLATED FROM NERVE CELLS, DNA SEQUENCES ENCODING SAME AND USAGES THEREOF

摘要

The present invention is based on the identification of four novel protein tyrosine kinases (PTKs) isolated from the postsynaptic density (PSD). These PTKs, whose molecular weights were approximately 166, 90, 66, and 50 kDa, as shown in the figure, were found to be resistant to Genistein, did not crossreact with antibodies which bind to other PTKs known in the art. The present invention further discloses previously unidentified proteins, isolated from the PSD, which have molecular weights of approximately 110, 120 and 270 kDa. These proteins were found to crossreact with an antibody which is selective for dystrophin.