| 摘要 |
The present invention relates to novel human and simian immunodeficiency viruses (HIVs and SIVs, respectively) having at least one mutation in the r &cir& _e &cir& _v &cir& _ (the regulator of virion-protein expression) gene of HIV or SIV genome rendering them replication deficient for the r &cir& _e &cir& _v &cir& _ gene, which can be transcomplemented. The present invention further relates to methods for producing said mutated viruses, vaccines containing said live, attenuated viruses, and methods of prevention and/or treatment of HIV and/or SIV infections or acquired immunodeficiency syndrome (AIDS) and related diseases in primates, including humans by administering a vaccine containing said mutated virus to afford protection against a virulent wild type HIV and/or SIV to an individual in the need thereof. |
