| 摘要 |
An angiotensin II type 2 receptor (AT2 receptor), structurally related cell receptors, nucleic acids encoding such AT2 receptors, AT2 receptor-related peptides, and methods of using AT2 receptors and AT2 receptor-encoding nucleic acids are provided. AT2 receptor-specific binding compounds are disclosed including antibodies to AT2 receptor epitopes. The invention provides AT2 receptor-based pharmaceutical compositions and AT2 receptor-based methods for screening chemical libraries for regulators of cell growth/differentiation. In particular, the invention provides methods for identifying agonists and antagonists of the disclosed AT2 receptor. Such compositions find broad utility in the treatment of cardiovascular disease, cancer, reproductive disease, etc.
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