USE OF QUINOLINE-3-CARBOXAMIDE COMPOUNDS FOR INHIBITING THE PRODUCTION OF TUMOUR NECROSIS FACTOR (TNF) AND/OR FOR THE TREATMENT OF SEPTIC SHOCK

摘要

The use of a quinoline-3-carboxamide compound comprising structure (I), optionally with substituents for the hydrogen atoms shown (H<1-9>), and a salt of compound (I) where (a) -------- represents that there are two conjugated double bonds between the atoms comprised by the dashed line, (b) X1 and X2 are separately selected form an oxygen atom or an NH<9> group, said X1 and X2 being bound by a single bond to the ring when attached to H<7> or H<8> and by a double bond when not bound to H<7> or H<8>, (c) H<1-9> are hydrogens with the provision that H<9> is only present when at least one of X1 and X2 is the NH<9> group, (d) H<7> and H<8> are hydrogens that are attached to different atoms selected among X1, X2 and the nitrogen atom (N) in the quinoline ring, for the manufacture of a composition intended for inhibiting the production of tumour necrosis factor (TNF) in a living body and/or the treatment of septic shock in a living body.