NICKEL-FREE HEMOGLOBIN AND METHODS FOR PRODUCING SUCH HEMOGLOBIN
摘要
According to the present invention removal of nickel from a nickel-containing hemoglobin solution is accomplished by exposing the nickel-containing hemoglobin solution to a chelating agent, preferably a multidentate acetic acid based chelator such as EDTA. Methods are provided that allow obtaining essentially nickel-free hemoglobin from nickel-containing hemoglobin solutions, particularly hemoglobin solutions that result from large scale fermentation and/or purification.
申请公布号
WO9503322(A1)
申请公布日期
1995.02.02
申请号
WO1994IB00225
申请日期
1994.07.22
申请人
SOMATOGEN, INC.;CHIVERS, MARK, L.;BELVAL, THOMAS, K.