发明名称 |
Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
摘要 |
Methods for preparing oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. In preferred embodiments, the methods involve reductive coupling of 3'- and 4'-substituted or 4'- and 3'-substituted nucleosidic synthons.
|
申请公布号 |
US5386023(A) |
申请公布日期 |
1995.01.31 |
申请号 |
US19930040903 |
申请日期 |
1993.03.31 |
申请人 |
|
发明人 |
|
分类号 |
A61K47/48;C07D405/04;C07D405/14;C07F7/18;C07H19/00;C07H19/04;C07H19/06;C07H19/10;C07H19/16;C07H21/00;(IPC1-7):C07H1/00 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|