| 摘要 |
<p>PURPOSE:To obtain the inhibiting agent containing an amine derivative expressed by a specific structural formula, having action to inhibit the chemotaxis induced by a monocyte chemotactic factor and useful for the treatment and prevention of arteriosclerosis, etc. CONSTITUTION:This inhibiting agent contains an aryloxypropanolamine derivative of the formula [R1 is branched lower alkyl, preferably isopropyl; R2 is H, halogen, 1-4C alkyl, etc.; R3 is H or 1-4C alkyl; preferably R2 and R3 together form unsubstituted 6C unsaturated carbon ring; R4 is H, (substituted) 1-4C alkyl, etc.; R5 is H, halogen, etc.] and its pharmacologically allowable acid addition salt as an active component.</p> |
