| 发明名称 |
Spiro-substituted azacycles as neurokinin antagonists |
| 摘要 |
Disclosed are spiro-substituted azacycles of formula (I), tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma. In particular compounds of formula (I) are shown to be neurokinin antagonists. |
| 申请公布号 |
ZA9403946(B) |
申请公布日期 |
1995.01.20 |
| 申请号 |
ZA19940003946 |
申请日期 |
1994.06.06 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
MALCOLM MACCOSS;SANDER G MILLS;SHRENIK K SHAH;YUAN-CHING P CHIANG;PATRICK T DUNN;HIROO KOYAMA;PAUL E FINKE;HONGBO QI;ALBERT J ROBICHAUD |
| 分类号 |
C07D487/20;A61K31/435;A61K31/44;A61K31/47;A61P1/00;A61P9/08;A61P21/00;A61P25/02;A61P27/16;C07D471/10;C07D491/10;C07D491/107;C07D495/10;C07D495/20;C07D513/20 |
主分类号 |
C07D487/20 |
| 代理机构 |
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