| 发明名称 |
INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE |
| 摘要 |
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compound of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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| 申请公布号 |
CA2165176(A1) |
申请公布日期 |
1995.01.05 |
| 申请号 |
CA19942165176 |
申请日期 |
1994.05.19 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
GRAHAM, SAMUEL L.;WILLIAMS, THERESA M. |
| 分类号 |
C12N9/99;A61K31/38;A61K31/381;A61K31/44;A61K31/4427;A61K31/443;A61K31/4433;A61K31/47;A61K31/472;A61K31/495;A61K31/505;A61P35/00;A61P43/00;C07D213/74;C07D215/48;C07D215/50;C07D217/26;C07D241/04;C07D295/13;C07D295/18;C07D295/192;C07D307/79;C07D333/24;C07D401/04;C07D401/06;C07D401/12;C07D403/06;C07D405/04;C07D405/06;C07D409/06;(IPC1-7):C07D241/04;C07D401/02;C07D471/04;C07D413/06;C07D417/06;C07D243/08;A61K31/55 |
主分类号 |
C12N9/99 |
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