NICOTINAMIDE RIBONUCLEOTIDE ISOSTERS, ISOSTERIC NAD ANALOGUES. THEIR SYNTHESES AND USE IN TREATMENTS OF ALCOHOLISM AND NEOPLASTIC DISEASES

摘要

This invention provides a compound having structure (I) wherein R<1>, R<2>, and R<3> are same or different, and are hydrogen, hydroxyl, or fluorine; Z is O, CH2 or CF2; R is chlorine, bromine, iodine, carbonitrile, carboxylic ester, or carboxamide; and one of W, X and Y is N or N<+>R', wherein R' is methyl or ethyl, and all others are CH; provided that R<1> is not H when R<2> and R<3> are OH, Z is O, R is carboxamide and W is N or N<+>R'. This invention also provides methods of preparing the compounds and a method of treating a mammal having a NAD-dependent enzyme associated disorder.