NOVEL PROTEIN HAVING AVIDITY WITH HEPARIN-BINDING GROWTH FACTOR

摘要

A protein having a molecular weigth of about 200 kDa as determined by SDS-PAGE conducted under reductive conditions and an amino acid sequence represented by Sequence Listing (1) at the terminal, in particular, a protein originating in an animal brain and having an avidity with heparin-binding growth factors, e.g., OSF-1. The protein is useful as a remedy for disorders of nerve functions or osteogenetic ability, because it combines with OSF-1 (HBGF-8), one of the heparin-binding growth factors having the activities of promoting neuron differentiation and proliferating osteoblasts, to thereby control the action of OSF-1.