发明名称 Monoacetic derivatives of the peptides leu-phe-ala and ala-leu-phe and their use in identifying and destroying tumour cells, viruses and virus-carrying cells.
摘要 <p>The monoacetic derivatives of tripeptides leucine-phenylalanine-alanine and alanine-leucine-phenylalanine are effective in activating NK lymphocytes to identify and destroy directly, that is without any interference by the immune system, aberrant tumour cells, metastatic cells, viruses and virus-carrying cells, so as to result in an "active immunotherapy". The invention also concerns the use of the said monoacetyl-tripeptides in the treatment and prophylaxis of cancer and viral diseases, as well as the pharmaceutical compositions containing one or both of the said compounds, together wit a suitable carrier and, optionally, with other pharmaceutically active substances. &lt;IMAGE&gt;</p>
申请公布号 EP0627444(A1) 申请公布日期 1994.12.07
申请号 EP19940830111 申请日期 1994.03.16
申请人 GRIPPA, LEONIDA 发明人 GRIPPA, LEONIDA
分类号 A61K38/06;A61K38/00;C07K5/083;(IPC1-7):C07K5/08;A61K37/02 主分类号 A61K38/06
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