发明名称 |
Hapalosiphon hibernicus |
摘要 |
New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
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申请公布号 |
US5366890(A) |
申请公布日期 |
1994.11.22 |
申请号 |
US19930135931 |
申请日期 |
1993.10.13 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
BONJOUKLIAN, ROSEANNE;MOORE, RICHARD E.;PATTERSON, GREGORY M. L.;SMITKA, TIM A. |
分类号 |
A61K31/40;A01N43/38;A01N43/90;A61K31/403;A61P31/04;A61P35/00;C07D209/56;C07D209/70;C07D209/80;C07D491/06;C07D491/08;C12N1/12;C12P17/08;C12P17/10;C12P17/18;C12R1/89;(IPC1-7):C12N1/12;C12N1/20 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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