发明名称 |
PROCESS FOR PREPARING PERHYDROTHIAZEPINE DERIVATIVES |
摘要 |
Perhydrothiazepine derivatives of formula (I): <IMG> (I) (in which R1 represents an optionally substituted alkyl group, R2 represents a carboxy-protecting group or hydrogen and R4 and R5 are hydrogen, alkyl, cycloalkyl, aryl or heterocyclic) can be prepared by reacting together compounds of formulae (II) and (III): <IMG> (II) <IMG> (III) and then reacting the product with a haloacetic acid ester and, if necessary, removing one or both carboxy-protecting groups. The resulting compounds have valuable ACE inhibitory activity.
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申请公布号 |
CA1332943(C) |
申请公布日期 |
1994.11.08 |
申请号 |
CA19860518106 |
申请日期 |
1986.09.12 |
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
YANAGISAWA, HIROAKI;ISHIHARA, SADAO;ANDO, AKIKO;KANAZAKI, TAKURO |
分类号 |
C07K14/81;A61K31/55;A61K31/554;A61K38/00;A61K38/55;A61P9/12;A61P43/00;C07D209/00;C07D281/00;C07D281/06;C07D333/00;C07D333/18;C07D409/12;C07D417/04;C07D417/12;C07D417/14;C07D521/00;C07F7/10;C07K1/113;C07K5/06;C12N9/99;(IPC1-7):C07D281/06 |
主分类号 |
C07K14/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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