| 摘要 |
PCT No. PCT/DK94/00122 Sec. 371 Date May 25, 1995 Sec. 102(e) Date May 25, 1995 PCT Filed Mar. 24, 1994 PCT Pub. No. WO94/22905 PCT Pub. Date Oct. 13, 1994The present invention describes a method for controlled activation and degradation of FVII during purification whereby a solution of Factor VII is subjected to a number of chromatographic purification steps wherein Zn++ is present in at least one of the purification steps. The present invention also describes a method for controlled activation and degradation of FVII wherein a solution of FVII is applied to a number of anion exchange and immunoaffinity columns. |
