| 摘要 |
Methods and compositions are provided relating to novel IgE isoforms and their use in immune hypersensitivity diagnosis and treatment. The compositions include transcription and translation products of the immunoglobulin epsilon locus, specific probes for epsilon transcription products, and compounds which specifically bind epitopes of epsilon translation products. Novel products of the epsilon locus include the following transcription products and translation products thereof: CH4-M2" (SEQ ID NO:02, residues 1-107 and SEQ ID NO:06), CH4'-CH5-M1'-M2 (SEQ ID NO:02, residues 1-72, SEQ ID NO:03 and SEQ ID NO:05), CH4'-CH5-M2' (SEQ ID NO:02, residues 1-72, SEQ ID NO:03 and SEQ ID NO:07) and CH4'-CH5-M2" (SEQ ID NO:02, residues 1-72, SEQ ID NO:03 and SEQ ID NO:06). Such epsilon products, specific probes and binding compounds find use in methods and kits for immune hypersensitivity diagnosis and treatment. |
