RECOMBINANT PRODUCTION OF HUMAN PLATELET-DERIVED GROWTH FACTOR RECEPTORS AND FRAGMENTS

摘要

There is provided a purified and isolated recombinant nucleic acid of less than about 50 kbp comprising at least about 24 contiguous nucleotides which encode a human platelet-derived growth factor receptor (hPDGF-R) polypeptide segment consisting essentially of intracellular region of hPDGF-R. There is also provided a method for introducing a hPDGF-R activity to a cell, said method comprising the step of introducing an intracellular hPDGF-R protein fragment of at least about five hundred daltons to said cell. Further there is provided an isolated polypeptide of less than about 200 amino acids comprising a receptor kinase insert region.