发明名称 |
HUMAN B-LYMPHOBLASTOID CELL LINE SECRETING ANTI-GANGLIOSIDE ANTIBODY |
摘要 |
A human B-lymphoblastoid cell line which is identified as L612. The L612 cell line is an Epstein-Barr virus transformed cell line which secretes a human monoclonal antibody (L612) which is reactive with glycoconjugates having an epitope of terminal NeuAc PROPORTIONAL 2-3 Galactose residue such as GM3 and GM4 present on a variety of human tumor tissues. The L612 antibody is useful in treating patients with the epitope containing tumors and is also useful in raising anti-id antibodies for use as surrogate antigens and diagnostic reagents. |
申请公布号 |
WO9419457(A1) |
申请公布日期 |
1994.09.01 |
申请号 |
WO1994US01469 |
申请日期 |
1994.02.09 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
IRIE, REIKO, F. |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P35/00;C07K16/30;C07K16/42;C12N5/10;C12N5/22;C12P21/08;C12R1/91;(IPC1-7):C12N5/22;C07K15/28 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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