| 发明名称 |
New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase. |
| 摘要 |
Compounds of the formula <CHEM> the pharmaceutically acceptable salts thereof, wherein Q is a substituted pyridine or pyrimidine group and R<1> incorporates a hydrocarbon group of from 4 to 16 carbon atoms, are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents. |
| 申请公布号 |
EP0609960(A1) |
申请公布日期 |
1994.08.10 |
| 申请号 |
EP19940200437 |
申请日期 |
1990.09.13 |
| 申请人 |
PFIZER INC. |
发明人 |
MCCARTHY, PETER A.;HAMANAKA, ERNEST S.;WALKER, FREDERICK J.;CHANG, GEORGE;TRUONG, THIEN |
| 分类号 |
C12N9/99;A61K31/16;A61K31/17;A61K31/38;A61K31/381;A61K31/415;A61K31/4184;A61K31/425;A61K31/426;A61K31/428;A61K31/435;A61K31/44;A61K31/4406;A61K31/4418;A61K31/4427;A61K31/443;A61K31/4433;A61K31/47;A61K31/472;A61K31/495;A61K31/496;A61K31/50;A61K31/502;A61K31/505;A61K31/517;A61P3/06;A61P9/10;A61P43/00;C07C;C07C233/07;C07C233/25;C07C275/28;C07C275/34;C07C317/44;C07C323/52;C07C323/60;C07D213/70;C07D213/75;C07D215/36;C07D215/38;C07D215/40;C07D217/02;C07D235/28;C07D237/28;C07D237/30;C07D239/48;C07D239/50;C07D239/52;C07D239/56;C07D239/58;C07D239/60;C07D239/74;C07D277/20;C07D277/36;C07D277/74;C07D277/82;C07D307/38;C07D307/64;C07D333/18;C07D401/04;C07D401/12;C07D403/12;C07D405/12;C07D409/12;C07D417/12;C07D471/04 |
主分类号 |
C12N9/99 |
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