发明名称 |
Method for increasing sensitivity to chemically induced terminal differentiation |
摘要 |
The present invention provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises treating the cells so as to render them resistant to an antitumor agent and contacting the resulting resistant cells under suitable conditions with an amount of a compound effective to selectively induce terminal differentiation of such cells. The compound has a structure: [R-A ]-B-[A1-B1-]a[A2-B2-]b[A3-R1]. The invention also concerns a method of treating a patient having a tumor characterized by proliferation of neoplastic which comprises administering to the patient an amount of an antitumor agent to render the cells resistant to the antitumor agent and subsequently administering to the patient an amount of the compound effective to selectively induce terminal differentiation of such neoplastic cells and thereby inhibit their proliferation.
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申请公布号 |
US5330744(A) |
申请公布日期 |
1994.07.19 |
申请号 |
US19880270643 |
申请日期 |
1988.11.14 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
PONTREMOLI, SANDRO;BRESLOW, RONALD;MARKS, PAUL A.;RIFKIND, RICHARD A. |
分类号 |
A61K31/16;A61K31/475;(IPC1-7):A61K49/00;A61K31/205 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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