| 摘要 |
<p>Methods and compositions for inhibiting the hepatic clearance of tissue-type plasminogen activator (t-PA) in vivo by administering a t-PA-hepatic clearance-inhibiting amount of 39kDa protein or a t-PA-hepatic clearance-inhibiting fragment thereof, or genetically or chemically modified forms of the 39kDa protein or fragments thereof are described. Compositions for treatment of thrombolytic diseases comprised of t-PA and a t-PA-hepatic clearance-inhibiting effective amount of 39kDa protein, a t-PA-hepatic clearance inhibiting fragment thereof, and genetically or chemically modified forms of the 39kDa protein or its fragments are described.</p> |
