| 摘要 |
<p>The present invention relates to a gastrocytoprotective pharmaceutical composition containing as active agents a compound of general formula (I), wherein R means hydrogen or a C1-4alkyl group; R1 stands for: hydroxyl group; C¿1-4?alkoxy group; or a group of general formula (A), wherein R?2¿ means hydrogen or benzyl group; and R3 means a C¿1-4?alkyl group; or stands for a group of general formula (B), wherein R?4¿ means a C¿1-4?alkyl group, and ranitidine in a weight ratio of 10:1 to 1:10 together with carriers and auxiliaries known per se, and to a process for the preparation thereof. A favourable active agent of general formula (I) is e.g. methyl 4-(3-carboxy-4-hydroxyphenyl)-4-oxo-(2E)-butenoate. The combination of the above active agents according to the invention exerts also an antibacterial effect (against the Helicobacter pylori strain).</p> |
