AMINOACID DERIVATIVES OF HETEROCYCLES AS PROTEIN KINASE C INHIBITORS

摘要

Described are aminoacid derivatives of the general formula (I), A-X-Y-En-R<5> in which A is a group of the general formula (III) in which R<1> is hydrogen or a lower-alkyl group with 1 to 4 carbon atoms and (- - -) is open or a bond. Also described is the use of such derivatives as inhibitors of protein kinase C in the treatment and/or prevention of cancer, viral infections, heart and circulatory disorders, thrombosis, cardiac-rythm irregularities, atherosclerosis, bronchopulmonary illnesses, degenerative conditions of the central nervous system, inflammatory illnesses, diseases of the immune system and psoriasis, and the use of such derivatives as immunosuppressants.