| 摘要 |
A dermal patch (90) to be worn on the skin for increasing the concentration of an analyte expressed through the skin in perspiration to a conveniently measurable level. Included are patches and methods of using such patches to determine the quantity of an analyte in a given volume of perspiration, to determine a subject's sensitivity to an allergen, to allow an analyte to be detected with conventional detection systems, and to dissolve the structural components of a patch to facilitate analyte detection. In addition, by delivering electricity to the patch, adding a buffer to the concentration zone (14) of the patch, or otherwise controlling the pH of fluids entering the patch, analytes in perspiration can be concentrated on the patch without the occurrence of significant back-diffusion of the analytes. Also, by generating heat on the surface of the skin of a subject wearing the patch, perspiration can be collected over a much shorter period of time, preferably over the course of about an hour. |
