| 摘要 |
PURPOSE:To prepare the title compound useful as an intermediate of pharmaceuticals, penicilin and cephalosporin derivatives, in high yield, by reacting a penicillin-1-oxide derivative with acetic acid anhydride in the presence of Mg. CONSTITUTION:A derivative of 2-acetoxymethyl-2-methyl penam-3-carboxylic acid II is prepared by reacting a penicillin-1-oxide I (R<1> is amino or substituted amino; R<2> is carboxy-protecting group) with acetic acid anhydride in the presence of Mg. The reaction is pref. carried out in an organic solvent such as pentane or hexane, at 70-150 deg.C for 0.5-20 hours, using excessive Mg and acetic acid anhydride. |
