发明名称 |
Method of inducing a histamine agonist action on H2 receptors |
摘要 |
The invention claims as drugs which are active as agonists of the histamine H3 receptor, the O-[2-(4(5-imidazolyl)-ethyl] isothiourea, 4-(4(5)-imidazolyl) butyramidine and S-[2-(4(5)-imidazolyl)-ethyl] isourea as well as their N-methyl derivatives, these compounds being useful for the preparation of drugs to be used as hypnotic, sleep-inducer, tranquillizer, sedative, anxiolytic, anti-asthmatic and anti-inflammatory agents, notably for the bronchi, the skin or the eyes, or as anti-gastric ulcer agents.
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申请公布号 |
US5321039(A) |
申请公布日期 |
1994.06.14 |
申请号 |
US19910754914 |
申请日期 |
1991.09.06 |
申请人 |
SOCIETE CIVILE BIOPROJET;INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) |
发明人 |
SCHWARTZ, JEAN C.;GARBARG, MONIQUE;ARRANG, JEAN M.;GANELLIN, CHARON R.;LECOMTE, JEANNE M. |
分类号 |
A61K31/415;A61P1/04;A61P11/00;A61P11/08;A61P17/00;A61P25/04;A61P25/06;A61P25/20;A61P27/02;A61P29/00;C07D233/54;C07D233/64;(IPC1-7):A61K31/415;C07D233/66;C07D233/88 |
主分类号 |
A61K31/415 |
代理机构 |
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