FO-2546 SUBSTANCE, ITS PRODUCTION AND ITS USE AS INHIBITOR OF ACYL-COA CHOLESTEROL ACYLTRANSFERASE

摘要

FO-2546 substance of formula (I) comprising FO-2546A substance, FO-2546B substance, FO-2546C substance and FO-2546D substance, FO-2546I substance, FO-2546J substance and FO-2546K substance, which has inhibitory activity for acylcoenzyme A cholesterol acyltransferase is produced by culturing microorganism strain FO-2546 belonging to Coelomycetes. The substance is useful for treatment and prevention of a disease attributed by accumulation of cholesterol.