发明名称 |
GENE FOR CODING FACTOR VIII C |
摘要 |
<p>(1) Protein compsn. (free from other proteins) showing a biological activity of Factor VIIIC and being a complex of an 80 kd and 77 kd protein calcium bridged with a 92.5 kd protein is new. (2) Human protein compsn. comprising 1 or 2 polypeptides of 67-80 kd and having an amino acid sequence of formula (I) in the N-terminal half of the polypeptide and having a biological activity of Factor VIIIC is new. (3) Human protein compsn. comprising a polypeptide of 92.5 kd and having an amino acid sequence of formula (II) in the N-terminal half of the polypeptide and having a biological activity of Factor VIIIC. (4) Monoclonal antibody prepd. with a protein compsn. as defined in paragraphs (1)-(3) is new. (5) Detection of a polynucleotide sequence encoding for at least part of Factor VIIIC comprises hybridising it, in single-stranded form, with a probe (III) and then isolating polynucleotide duplexing with the probe.</p> |
申请公布号 |
JPH06105688(A) |
申请公布日期 |
1994.04.19 |
申请号 |
JP19930092775 |
申请日期 |
1993.04.20 |
申请人 |
CHIRON CORP;NOVO NORDISK AS |
发明人 |
JIYOOJI KUO;FURANKU AARU MASHIYAAZU;MAASA TOURUUTO;PABURO BARENZUERA;MIRERA EZUBAN RASUMUSEN;JIENIFUAA FUABARORO |
分类号 |
C12N15/09;A61K35/14;A61K35/16;A61K38/00;A61K38/16;A61K38/43;A61K39/395;A61P7/04;C07H21/04;C07K14/00;C07K14/435;C07K14/755;C07K16/00;C07K16/36;C12N1/21;C12N5/10;C12N15/00;C12N15/12;C12P21/02;C12Q1/68;C12R1/91;G01N33/53;G01N33/86;(IPC1-7):C12N15/12 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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