VECTOR TO DELIVER AND EXPRESS FOREIGN GENE

摘要

A vector for delivering a foreign gene to a target cell for expression of the foreign gene is provided. The vector comprises a (-) sense RNA genome contained within a ribonucleoprotein complex within a virus-like particle constituted from structural proteins of a (-) sense RNA virus. The (-) sense RNA genome includes one or more foreign genes but does not include genes for replication of the (-) sense RNA virus. Methods of preparing the vector are disclosed, as well as pharmaceutical compositions containing the vector, and methods of delivering the expression product of the foreign gene to a target cell.