| 摘要 |
<p>Compositions for concentrating a therapeutic agent in an inflamed tissue region, and particularly an inflamed dermal region, are disclosed. The composition is a liposomal composition. The liposomes contain the therapeutic compound in entrapped form and are composed of vesicle-forming lipids including a vesicle-forming lipid derivatized with polyethylene glycol. After intravenous administration, the liposomes are taken up by the inflamed region within 24-48 hours, for site-specific release of and concentration of the therapeutic compound into the inflamed region.</p> |
