Neue Benzopyranone, Verfahren zu ihrer Herstellung und Verwendung

摘要

Described are 2H-1-benzopyran-2-ones (coumarin derivatives) of general formula (I) in which R<1> is a hydroxyl group, a lower-alkoxy group, a cycloalkoxy group with 4 to 6 C-atoms or the alkyl- or arylsulphonyloxy group R<6>-SO2O-; R<2> and R<3>, independently of each other, are hydrogen atoms, hydroxyl groups, lower-alkyl groups or cycloalkoxy groups with 4 to 6-atoms; R<4> is a hydrogen atom, a lower-alkyl group with 1 to 4 C-atoms or a phenyl group; Y is a nitrogen atom, a CH group or a COH group; R<5> is a phenyl, naphthyl, pyridinyl or pyrimidinyl group which may optionally be substituted by one or two C1-C5 alkyl groups, by one or two halogen atoms, by a halogen and C1-C5 alkyl together, by perfluoroalkyl with 1 to 3 C-atoms by C1-C5 alkoxy, by hydroxy, by methylenedioxy or by nitro; R<6> is a lower-alkyl group, a cycloalkyl group with 4 to 6 C-atoms or a phenyl group which may optionally be substituted by one or two C1-C5 alkyl groups, by one or two halogens atoms, or by perfluoroalkyl with 1 to 3 C-atoms; and n = 1 to 4; plus their addition compounds with physiologically tolerated acids. Also described are methods of preparing these compounds, intermediates in their preparation and methods of preparing such intermediates. The coumarin derivatives described possess a neuroprotective and psychopharmacological action. The invention also concerns drugs containing these compounds.