摘要 |
A compound of the formula I (* CHEMICAL STRUCTURE *) I wherein: R1 is hydrogen, (1-6C)alkyl, or (1-4C)alkanoyl; R2 is phenyl, a C-linked aromatic 5- or 6-membered heterocyclic ring containing one of oxygen and sulphur and/or one or two nitrogen, or (1-8C)alkyl, alkenyl or alkynyl unsubstituted or substituted by a phenyl or a C-linked aromatic 5- or 6-membered heterocylic ring containing one of oxygen and sulphur and/or one or two nitrogen, any phenyl being unsubstituted or substituted by one, two or three of (1-4C)alkyl, (1-4C)alkoxy, halogen, trifluoromethyl, hydroxy, benzyloxy and (1-5C)alkanoyloxy; A is N or CT in which T is hydrogen or (1-4C)alkyl; or a pharmaceutically acceptable salt thereof, processes for the manufacture of the compounds, and pharmaceutical compositions containing them. The compounds are useful as adenosine antagonists.
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申请人 |
IMPERIAL CHEMICAL INDUSTRIES, PLC |
发明人 |
CAULKETT, PETER W. R.;JONES, GERAINT;COLLIS, MICHAEL G.;POUCHER, SIMON M. |