发明名称 Azole derivatives
摘要 A compound of the formula I (* CHEMICAL STRUCTURE *) I wherein: R1 is hydrogen, (1-6C)alkyl, or (1-4C)alkanoyl; R2 is phenyl, a C-linked aromatic 5- or 6-membered heterocyclic ring containing one of oxygen and sulphur and/or one or two nitrogen, or (1-8C)alkyl, alkenyl or alkynyl unsubstituted or substituted by a phenyl or a C-linked aromatic 5- or 6-membered heterocylic ring containing one of oxygen and sulphur and/or one or two nitrogen, any phenyl being unsubstituted or substituted by one, two or three of (1-4C)alkyl, (1-4C)alkoxy, halogen, trifluoromethyl, hydroxy, benzyloxy and (1-5C)alkanoyloxy; A is N or CT in which T is hydrogen or (1-4C)alkyl; or a pharmaceutically acceptable salt thereof, processes for the manufacture of the compounds, and pharmaceutical compositions containing them. The compounds are useful as adenosine antagonists.
申请公布号 US5290776(A) 申请公布日期 1994.03.01
申请号 US19920886798 申请日期 1992.05.21
申请人 IMPERIAL CHEMICAL INDUSTRIES, PLC 发明人 CAULKETT, PETER W. R.;JONES, GERAINT;COLLIS, MICHAEL G.;POUCHER, SIMON M.
分类号 A61K31/53;A61P9/00;A61P9/08;C07D487/04;(IPC1-7):C07D405/14;A51K31/53 主分类号 A61K31/53
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