发明名称 |
MAMMALIAN MULTIPOTENT NEURAL STEM CELLS |
摘要 |
The invention includes mammalian multipotent neural stem cells and their progeny and methods for the isolation and clonal propagation of such cells. At the clonal level the stem cells are capable of self regeneration and asymmetrical division. Lineage restriction is demonstrated within developing clones which are sensitive to the local environment. The invention also includes such cells which are transfected with foreign nucleic acid, e.g., to produce an immortalized neural stem cell. The invention further includes transplantation assays which allow for the identification of mammalian multipotent neural stem cells from various tissues and methods for transplanting mammalian neural stem cells and/or neural or glial progenitors into mammals. A novel method for detecting antibodies to neural cell surface markers is disclosed as well as a monoclonal antibody to mouse LNGFR.
|
申请公布号 |
CA2140884(A1) |
申请公布日期 |
1994.02.03 |
申请号 |
CA19932140884 |
申请日期 |
1993.07.26 |
申请人 |
CALIFORNIA INST OF TECHN |
发明人 |
ANDERSON DAVID J;STEMPLE DEREK L |
分类号 |
A01K67/027;C12N5/0797;C12N5/10;C12N15/09;C12P21/08;C12R1/91;G01N33/577;(IPC1-7):C12N5/00;C07K16/28;G01N33/554;G01N33/566 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|