Fused benzeneoxyacetic acid derivatives and their use as PG12 antagonists.

摘要

A fused benzeneoxyacetic acid derivative of the formula: <CHEM> wherein <CHEM> is (i) <CHEM> (ii) <CHEM> (iii) <CHEM> or (iv) <CHEM> A is (i) <CHEM> or (ii) <CHEM> R<1> is hydrogen or C1-4 alkyl; R<2> is hydrogen, C1-6 alkyl or phenyl; R<3> is (i) C1-15 alkyl, (ii) C1-8 alkyl substituted by one or two of benzene, C4-7 cycloalkane or 4-7 ring-membered monocyclic ring which contains one nitrogen atom or (iii) C10-15 condensed tricyclic ring; e is 3-5; f is 1-3; p is 0-4; q is 0-2; s is 0-3 With the proviso that, ring(s) in R<3> may be substituted by one to three of C1-4 alkyl, 1-4 alkoxy, halogen atom, nitro or trihalomethyl. And, when D -- B is the formula (iii) or (iv), -(CH2)p- or =CH-(CH2)s- is attached at the position of a or b on the ring. and non-toxic salts thereof possess an antagonistic activity on PGI2 receptor, so it is useful for prevention and/or treatment of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension.