发明名称 Method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function
摘要 This invention is directed to a composition comprising a substantially purified protein which enhances endogenous stimulus-induced neurotransmitter release, said neurotransmitter being selected from the group consisting of acetylcholine, dopamine or serotonin, said protein having a binding affinity constant of at least 2.9+-0.8 nM for tritiated 3,3-bis(4-pyridinylmethyl)-1-phenylindolin-2-one as determined by a Scatchard analysis, and said protein being trypsin sensitive and phospholipase C insensitive.
申请公布号 US5278045(A) 申请公布日期 1994.01.11
申请号 US19900486484 申请日期 1990.02.28
申请人 DU PONT MERCK PHARMACEUTICAL COMPANY 发明人 TAM, SANG W.
分类号 A61K39/395;C07K14/00;C07K14/705;C07K16/00;C07K16/28;C07K19/00;G01N33/53;G01N33/577;G01N33/68;G01N33/94;(IPC1-7):G01N33/53 主分类号 A61K39/395
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