OXAZOLE DERIVATIVES AND THEIR USE AS ANTIULCER AGENTS AND H2-RECEPTOR ANTAGONIST

摘要

A compound of formula (I) wherein R<1> is amino which may have suitable substituent(s), R<2> and R<3> are each hydrogen or aliphatic hydrocarbon group which may have suitable substituent(s), A is lower alkylene, and Y is pyridinediyl or furandiyl, and a pharmaceutically acceptable salt thereof. The compound of the present invention possesses antiulcer activity and H2-receptor antagonism, and is useful for a therapeutic treatment of gastritis, ulcer (e.g. gastric ulcer, duodenal ulcer, anastomotic ulcer, etc.), Zollinger-Ellison syndrome, reflux esophagitis, upper gastrointestinal bleeding, and the like.