| 摘要 |
<p>The present invention provides a compound having structure (I) wherein R?1 and R2¿ are independently the same or different and are hydrogen, an acetyl group; an acyl group having the formula -CO(CH¿2?)nCOCH3, wherein n = 1-3; -CO(CH2)nCOOM, wherein n = 1-4 and M is hydrogen, Na or K; or -(CH2)nCOOR, wherein n = 1-4 and R is hydrogen, Na, K or an alkyl group having 1 to 5 carbon atoms; a hydroxyalkyl group having the formula -(CH2)nCH2OH, wherein n = 1-4; a halo alkyl group having the formula -(CH2)nCH2X, wherein n = 1-4 and X is a chloro, bromo, or iodo group; a metal sulfonate (-SO3M) wherein M is Na or K; a metal sulfinate (-SO2M) wherein M is Na or K; an alkyl sulfonate (-SO3R) wherein R is an alkyl group having 1 to 4 carbon atoms such as methyl, ethyl, n-propyl or i-propyl; an alkylsulfonyl group (-SO2R) wherein R is an alkyl group having 1 to 4 carbon atoms such as methyl, ethyl, n-propyl or i-propyl; a metal alkylsulfonate having the formula -(CH2)nSO3M wherein n = 2-3 and M is Na or K; a metal alkylsulfate having the formula -(CH2)nOSO3M wherein n = 2-3, and M is Na or K; or a β-alanyl group. The present invention also provides a process for synthesizing the above-identified compound, intermediate compounds produced thereby, a pharmaceutical composition comprising the above compounds as well as a method for inhibiting growth of tumor cells using these compounds.</p> |
