发明名称 |
Diagnosis of IDDM with a panel of immunoreagents. |
摘要 |
Diagnosis of insulin-dependent (Type I) diabetes mellitus (IDDM) by contacting a blood sample from a patient with an immunoreagent comprising epitopes of two or more of glutamic acid decarboxylase (GAD) and the pancreatic islet cell antigens referred to as ICA512 and ICA12. Binding of antibodies present in the blood sample with one or more of such epitopes correlates with IDDM or a potential for developing IDDM. In clinical testing, about 80 percent of sera from newly diagnosed IDDM patients react positively with at least one epitope in a GAD/ICA512 panel. Reactivity with the GAD/ICA512/ICA12 panel is between about 80 and 90 percent. The method is useful in screening patients for pre-IDDM, for distinguishing IDDM from Type II diabetes, and for monitoring therapy.
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申请公布号 |
EP0569800(A1) |
申请公布日期 |
1993.11.18 |
申请号 |
EP19930107064 |
申请日期 |
1993.04.30 |
申请人 |
MILES INC. |
发明人 |
RABIN, DANIEL U.;KNOWLES, WILLIAM J. |
分类号 |
G01N33/53;G01N33/564;G01N33/573;G01N33/68;G01N33/74;(IPC1-7):G01N33/573 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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