发明名称 |
5-O-DESOSAMINYLERYTHRONOLIDE A DERIVATIVE |
摘要 |
Object: to provide a novel macrolide antibiotic having a potent antibacterial activity. Constitution: a tricyclic carbamate derivative of a 3-oxo-6-methoxy-substituted 5-O-desosaminylerythronolide A derivative represented by general formula (I), and a pharmaceutically acceptable acid addition salt thereof. In formula (I), -A <SIGN> represents -N(R<3>)- (wherein R<3> represents hydrogen or C1-C3 alkyl) or -N=; and R<1> and R<2> represent each C1-C3 alkyl. An intermediate, represented by general formula (II), useful for producing the 3-oxo-substituted 5-O-desosaminylerythronolide A derivative, wherein R<4> represents acetyl or propionyl. |
申请公布号 |
WO9321200(A1) |
申请公布日期 |
1993.10.28 |
申请号 |
WO1993JP00517 |
申请日期 |
1993.04.21 |
申请人 |
TAISHO PHARMACEUTICAL CO., LTD. |
发明人 |
ASAKA, TOSHIFUMI;KASHIMURA, MASATO;MISAWA, YOKO;MORIMOTO, SHIGEO;HATAYAMA, KATSUO |
分类号 |
A61K31/395;C07D491/00;C07H17/00;C07H17/08;(IPC1-7):C07H17/00 |
主分类号 |
A61K31/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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