| 摘要 |
<p>A pyridylserine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 represents hydrogen or an amino-protecting group, R2 represents hydrogen or a carboxyl-protecting group, A represents a single bond or lower alkylene, B represents -NR3R4, or mercapto which may be substituted by lower alkyl or cycloalkyl, R?3 and R4¿ may be the same or different from each other and each represents hydrogen; a lower alkyl group which may be substituted by amino, lower alkylamino or carbocyclic aryl; an acyl group which may be substituted by amino; an aminocarbonyl group which may be substituted by lower alkyl or cycloalkyl; lower alkoxycarbonyl; cycloalkylcarbonyl; a nitrogenous heterocyclic group; or alternatively, R?3 and R4¿ may be combined together to represent a nitrogenous heterocyclic group, a fused nitrogenous heterocyclic group or a cross-linked nitrogenous heterocyclic group. It has an anti-PCP effect and is useful as a psychotropic.</p> |
